Hot melt extrusion (HME) is frequently used for amorphous solid dispersion preparation and subsequent solubility and bioavailability improvement of poorly water-soluble drugs. This technique can generate numerous structures, including granules, pallets, and filaments, according to the requirement. The present study investigates the fundamental factors affecting the properties of etoricoxib-Soluplus filaments prepared by the HME method for additive manufacturing applications. The theoretical and experimental understanding of the drug–polymer miscibility was evaluated initially. Further, a detailed investigation was done to understand the role of process and formulation variables on the quality and performance of the extruded filaments. Characterization of filaments was done by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and differential scanning calorimetry (DSC). The mechanical properties and ductility of the filaments were evaluated by texture analysis, tensile strength, and X-ray micro-computed tomography (μCT). The in vitro drug release study was performed to understand the release characteristics of the filaments. Further, the filaments were subjected to the feedability and printability study, which showed promising filament characteristics suitable for printing by the fused deposition modeling (FDM) technique. In a broader sense, such HME-based filaments, which are mostly amorphous solid dispersion in nature, can readily be used as printing ink for instant printing of personalized medicines of those drugs, which can withstand the conditions of hot melt extrusion, and FDM-based three-dimensional (3D) printing. Thus, the etoricoxib filament preparation method reported herein can be a promising approach for 3D printing applications and etoricoxib personalized therapy.

中文翻译：

---

用于增材制造的热熔挤出即印型依托考昔粗丝作为印刷油墨的机械化学评价


热熔挤出（HME）经常用于无定形固体分散体的制备以及随后难溶性药物的溶解度和生物利用度的提高。该技术可以根据要求生成多种结构，包括颗粒、托盘和细丝。本研究调查了影响用于增材制造应用的 HME 方法制备的依托考昔-Soluplus 长丝性能的基本因素。初步评估了对药物-聚合物混溶性的理论和实验理解。此外，还进行了详细的调查，以了解工艺和配方变量对挤出长丝的质量和性能的作用。通过傅里叶变换红外光谱 (FT-IR)、X 射线衍射 (XRD)、扫描电子显微镜 (SEM) 和差示扫描量热法 (DSC) 来表征长丝。通过织构分析、拉伸强度和 X 射线微计算机断层扫描 (μCT) 评估长丝的机械性能和延展性。进行体外药物释放研究是为了了解细丝的释放特性。此外，对长丝进行了送丝性和适印性研究，结果表明，长丝具有适合通过熔融沉积建模（FDM）技术进行打印的良好特性。从更广泛的意义上讲，这种基于HME的长丝本质上大多是无定形固体分散体，可以很容易地用作印刷油墨，用于即时打印这些药物的个性化药物，可以承受热熔挤出和FDM的条件。基于三维（3D）打印。 因此，本文报道的依托考昔丝制备方法可能是3D打印应用和依托考昔个性化治疗的有前途的方法。