Understanding the continuous crystallization process is of paramount interest in the industry. In this work, the continuous crystallization kinetics of cefradine in a three-stage mixed suspension mixed product removal (MSMPR) system was investigated at a steady state. In addition, the nucleation rate and growth rate of cefradine at different temperatures and stirring rates were determined on the basis of the population balance equation and further regressed on the basis of the different parameters. The results show that the crystal nucleation rate and growth rate are the fastest in the third stage and in the first stage, respectively. According to the regressed nucleation and growth rate models, the relative concentration had a smaller effect on the growth rate than that on the nucleation rate with a larger fitted parameter of relative concentration. The nucleation rate was significantly affected by the stirring rate with the largest fitted parameter of the stirring rate.

中文翻译：

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混合悬浮液混合产物去除系统中头孢拉定的连续结晶动力学

了解连续结晶过程是业界最感兴趣的。在这项工作中，研究了三级混合悬浮液混合产物去除（MSMPR）系统中稳态下头孢拉定的连续结晶动力学。此外，根据群体平衡方程确定了不同温度和搅拌速率下头孢拉定的成核速率和生长速率，并根据不同参数进一步回归。结果表明，晶体成核速率和生长速率分别在第三阶段和第一阶段最快。根据成核和生长速率回归模型，相对浓度拟合参数较大时，相对浓度对生长速率的影响小于对成核速率的影响。成核速率受搅拌速率的影响显着，其中搅拌速率的拟合参数最大。