The chemical space of chiral Brønsted acid catalysts is defined by quantity and complexity, reflecting the diverse synthetic challenges confronted and the innovative molecular designs introduced. Here, we detail how this successful outcome is a powerful demonstration of the benefits of utilizing both local structure searches and a comprehensive understanding of catalyst performance for effective and efficient exploration of Brønsted acid properties. In this concept article we provide an evolutionary overview of this field by summarizing the approaches to catalyst optimization, the resulting structures, and functions.

中文翻译：

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手性布朗斯台德酸结构的多样性和演化

手性布朗斯台德酸催化剂的化学空间由数量和复杂性定义，反映了面临的各种合成挑战和引入的创新分子设计。在这里，我们详细介绍了这一成功结果如何有力地证明了利用局部结构搜索和对催化剂性能的全面了解来有效和高效地探索布朗斯台德酸性质的好处。在这篇概念文章中，我们通过总结催化剂优化方法、所得结构和功能，提供了该领域的演变概述。