In the realm of cancer treatment, traditional modalities like radiotherapy and chemotherapy have achieved certain advancements but continue to grapple with challenges including harm to healthy tissues, resistance to treatment, and adverse drug reactions. The swift progress in nanotechnology recently has opened avenues for investigating innovative approaches to cancer therapy. Especially, chemodynamic therapy (CDT) utilizing metal nanomaterials stands out as an effective cancer treatment choice owing to its minimal side effects and independence from external energy sources. Transition metals like manganese are capable of exerting anti-tumor effects through a Fenton-like mechanism, with their distinctive magnetic properties playing a crucial role as contrast agents in tumor diagnosis and treatment. Against this backdrop, this review emphasizes the recent five-year advancements in the application of manganese (Mn) metal ions within nanomaterials, particularly highlighting their unique capabilities in catalyzing CDT and enhancing MRI imaging. Initially, we delineate the biomedical properties of manganese, followed by an integrated discussion on the utilization of manganese-based nanomaterials in CDT alongside multimodal therapies, and delve into the application and future outlook of manganese-based nanomaterial-mediated MRI imaging techniques in cancer therapy. By this means, the objective is to furnish novel viewpoints and possibilities for the research and development in future cancer therapies.

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锰基纳米材料在癌症诊断和化学动力学治疗中的新进展

在癌症治疗领域，放疗和化疗等传统疗法已经取得了一定的进步，但仍面临着健康组织损害、治疗耐药和药物不良反应等挑战。纳米技术最近的迅速进展为研究癌症治疗的创新方法开辟了途径。特别是，利用金属纳米材料的化学动力学疗法（CDT）因其副作用最小且不依赖外部能源而成为有效的癌症治疗选择。锰等过渡金属能够通过类芬顿机制发挥抗肿瘤作用，其独特的磁性在肿瘤诊断和治疗中作为造影剂发挥着至关重要的作用。在此背景下，本综述强调了最近五年锰（Mn）金属离子在纳米材料中应用的进展，特别强调了它们在催化 CDT 和增强 MRI 成像方面的独特能力。首先，我们概述了锰的生物医学特性，然后综合讨论了锰基纳米材料在CDT中与多模式疗法的应用，并深入探讨了锰基纳米材料介导的MRI成像技术在癌症治疗中的应用和未来展望。通过这种方式，目的是为未来癌症治疗的研究和开发提供新的观点和可能性。