A method has been developed for the rapid synthesis of highly substituted 3-methylpyridones via the condensation of Baylis–Hillman amines and ketones under benzoic acid catalysis. The process features readily available starting materials, broad substrate scope, high functional group tolerance, excellent regioselectivity, and gram-scale synthesis. We envision that this on-demand construction of 3-methylpyridones will provide exciting opportunities in biological research, therapeutics, and material sciences

中文翻译：

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高度取代的 3-甲基吡啶酮的模块化方法

开发了一种在苯甲酸催化下通过 Baylis-Hillman 胺和酮缩合快速合成高度取代的 3-甲基吡啶酮的方法。该工艺具有易得的起始材料、广泛的底物范围、高官能团耐受性、优异的区域选择性和克级合成能力。我们预计，这种 3-甲基吡啶酮的按需构建将为生物研究、治疗学和材料科学提供令人兴奋的机会