Lingzhu Pulvis is a classic formulation for treating febrile convulsions in children. However, Acorus tatarinowii essential oil (AT-EO) in this prescription is prone to volatilization and oxidation, compromising the efficacy and quality control of this formulation. Herein, based on the concept of “combination of medicine and adjuvant”, Pickering emulsion technology was applied to enhance the stability of AT-EO using modified amber as a stabilizer. Amber was a resinous medicinal powder in Lingzhu Pulvis and was modified into a suitable stabilizer for Pickering emulsion through surface modification. A thermal stability study indicated that Pickering emulsion, stabilized by modified amber, exhibited a higher retention rate of AT-EO and lower levels of peroxide value and malondialdehyde content compared to those of the pure AT-EO group after heat treatment at 40 °C for 1, 3, and 8 h. Additionally, component analysis in content and composition revealed that the volatile components of AT-EO in the Pickering emulsion were more stable during the thermal treatment process. This study convincingly illustrates the potential of a Pickering emulsion stabilized with modified medicinal powders to improve the thermal stability of the essential oil.

中文翻译：

---

改性琥珀颗粒作为稳定剂构建水包油 Pickering 乳液以提高石菖蒲精油的热稳定性

灵珠散是治疗小儿热性惊厥的经典方剂。然而，该配方中的石菖蒲精油（AT-EO）容易挥发和氧化，影响该配方的功效和质量控制。在此，基于“药辅结合”的理念，采用Pickering乳液技术，以改性琥珀作为稳定剂，增强AT-EO的稳定性。琥珀是灵珠散中的树脂状药粉，通过表面改性将其改性为适合皮克林乳剂的稳定剂。热稳定性研究表明，与纯 AT-EO 组相比，改性琥珀稳定的 Pickering 乳液在 40 °C 热处理后表现出更高的 AT-EO 保留率以及更低的过氧化值和丙二醛含量。 1、3 和 8 小时。此外，含量和成分分析表明，Pickering乳液中AT-EO的挥发性成分在热处理过程中更加稳定。这项研究令人信服地说明了用改性药用粉末稳定的皮克林乳液在提高精油热稳定性方面的潜力。