Neurohybrid systems have gained large attention for their potential as in vitro and in vivo platform to interrogate and modulate the activity of cells and tissue within nervous system. In this scenario organic neuromorphic devices have been engineered as bioelectronic platforms to resemble characteristic neuronal functions. However, aiming to a functional communication with neuronal cells, material synthesis, and surface engineering can yet be exploited for optimizing bio‐recognition processes at the neuromorphic‐neuronal hybrid interface. In this work, artificial neuronal‐inspired lipid bilayers have been assembled on an electrochemical neuromorphic organic device (ENODe) to resemble post‐synaptic structural and functional features of living synapses. Here, synaptic conditioning has been achieved by introducing two neurotransmitter‐mediated biochemical signals, to induce an irreversible change in the device conductance thus achieving Pavlovian associative learning. This new class of in vitro devices can be further exploited for assembling hybrid neuronal networks and potentially for in vivo integration within living neuronal tissues.

中文翻译：

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用神经元启发的支持脂质双层隐藏有机神经形态装置

神经混合系统因其作为体外和体内平台来询问和调节神经系统内细胞和组织活动的潜力而受到广泛关注。在这种情况下，有机神经形态设备已被设计为生物电子平台，以类似于特征神经元功能。然而，以与神经元细胞的功能性通信为目标，材料合成和表面工程仍可用于优化神经形态-神经元混合界面的生物识别过程。在这项工作中，人工神经元启发的脂质双层被组装在电化学神经形态有机装置（ENODe）上，以类似于活突触的突触后结构和功能特征。在这里，突触调节是通过引入两种神经递质介导的生化信号来实现的，以诱导设备电导的不可逆变化，从而实现巴甫洛夫联想学习。这种新型体外装置可进一步用于组装混合神经元网络，并有可能在活体神经元组织中进行体内整合。