An unprecedented 1,5‐addition/N‐1,4‐addition cascade reaction is established via palladium hydride catalysis. A variety of polysubstituted dihydropyrrole skeletons are constructed in high yield and with exclusively >20:1 diastereoselectivity. An enantioselective protocol of this design is also developed to provide a novel access to enantioenriched dihydropyrroles.

中文翻译：

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通过1,5-加成和N-1,4-加成级联立体选择性合成多取代二氢吡咯

通过氢化钯催化建立了前所未有的 1,5 加成/N-1,4 加成级联反应。以高产率构建了多种多取代二氢吡咯骨架，且非对映选择性仅 >20:1。还开发了该设计的对映选择性方案，以提供对映富集的二氢吡咯的新途径。