Thrombolytic enzymes constitute a class of proteases with antithrombotic functions. Derived from natural products and abundant in nature, certain thrombolytic enzymes, such as urokinase, earthworm kinase, and streptokinase, have been widely used in the clinical treatment of vascular embolic diseases. Fly maggots, characterized by their easy growth and low cost, are a traditional Chinese medicine recorded in the Compendium of Materia Medica. These maggots can also be used as raw material for the extraction and preparation of thrombolytic enzymes (maggot kinase). In this review, we assembled global research reports on natural thrombolytic enzymes through a literature search and reviewed the functions and structures of natural thrombolytic enzymes to provide a reference for natural thrombophilic drug screening and development.

中文翻译：

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蛆激酶和天然溶栓蛋白

溶栓酶是一类具有抗血栓功能的蛋白酶。某些溶栓酶来源于天然产物，在自然界中含量丰富，如尿激酶、蚯蚓激酶、链激酶等，已广泛应用于血管栓塞性疾病的临床治疗。蝇蛆具有生长容易、成本低廉的特点，是《本草纲目》中记载的中药材。这些蛆虫还可以作为提取和制备溶栓酶（蛆激酶）的原料。本文通过文献检索，整理了全球天然溶栓酶的研究报告，综述了天然溶栓酶的功能和结构，为天然溶栓药物的筛选和开发提供参考。