Photoaging is the premature aging of the skin caused by prolonged exposure to solar radiation. The visual alterations manifest as wrinkles, reduced skin elasticity, uneven skin tone, as well as other signs that surpass the expected outcomes of natural aging. Beyond these surface changes, there is a complex interplay of molecular alterations, encompassing shifts in cellular function, DNA damage, and protein composition disruptions. This data descriptor introduces a unique dataset derived from ten individuals, each with a minimum of 18 years of professional experience as a driver, who are asymmetrically and chronically exposed to solar radiation due to their driving orientation. Skin samples were independently collected from each side of the face using a microdermabrasion-like procedure and analyzed on an Exploris 240 mass spectrometer. Our adapted proteomic statistical framework leverages the sample pairing to provide robust insights. This dataset delves into the molecular differences in exposed skin and serves as a foundational resource for interdisciplinary research in photodermatology, targeted skincare treatments, and computational modelling of skin health.

光老化是由于长期暴露在太阳辐射下导致的皮肤过早老化。视觉变化表现为皱纹、皮肤弹性降低、肤色不均匀以及其他超出自然衰老预期结果的迹象。除了这些表面变化之外，还存在分子变化的复杂相互作用，包括细胞功能的变化、DNA 损伤和蛋白质组成的破坏。该数据描述符引入了来自 10 个人的独特数据集，每个人都至少拥有 18 年的驾驶员专业经验，由于驾驶方向的原因，这些人长期不对称地暴露在太阳辐射下。使用类似微晶磨皮的程序从脸部两侧独立收集皮肤样本，并在 Exploris 240 质谱仪上进行分析。我们改编的蛋白质组统计框架利用样本配对来提供可靠的见解。该数据集深入研究了暴露皮肤的分子差异，并作为光皮肤学、针对性皮肤护理治疗和皮肤健康计算模型等跨学科研究的基础资源。