Since antibiotics abuse has brought the severe threat to ecosystem and human health, the monitoring of antibiotics in the environment is drawing increased interest. In this work, a rare 2:2 supramolecular host-guest complex () was successfully constructed by encapsulating the guest molecule 1,4-bis(2-benzimidazol-2-yl) benzene () into the cavity of cucurbit[8]uril (Q[8]). It was found that the fluorescence of () was quenched significantly upon the formation of host-guest system and then could be selectively recovered in the presence of gentamicin (GEN) owing to the displacement of guest molecules. Fluorescence titration experiments indicated that the formed supramolecular complex could function as a quantitative fluorescence sensor for GEN in the low concentration range with the limit of detection (LOD) of 0.17 μM. Furthermore, also showed excellent practicability and reliability for the detection of GEN in milk samples.

中文翻译：

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一种新型葫芦[8]脲2:2超分子复合物用于牛奶中庆大霉素的荧光传感


由于抗生素的滥用给生态系统和人类健康带来了严重威胁，环境中抗生素的监测越来越受到人们的关注。本工作通过将客体分子1,4-双(2-苯并咪唑-2-基)苯()封装到葫芦[8]脲的空腔中，成功构建了一种罕见的2:2超分子主客体复合物() （问题[8]）。结果发现，()的荧光在主客体系统形成后显着猝灭，然后由于客体分子的置换，在庆大霉素(GEN)存在下可以选择性地恢复。荧光滴定实验表明，形成的超分子复合物可以作为低浓度范围内GEN的定量荧光传感器，检测限（LOD）为0.17 μM。此外，对于牛奶样品中GEN的检测也表现出了良好的实用性和可靠性。