Recently in Cell Metabolism, Wei et al.¹ unveiled a brain-to-gut pathway that conveys psychological stress to intestinal epithelial cells, leading to their dysfunction. This gut-brain axis involves a microbial metabolite, indole-3-acetate (IAA), as a niche signal that hampers mitochondrial respiration to skew intestinal stem cell (ISC) fate.

中文翻译：

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微生物代谢物在压力下控制肠道干细胞的命运

最近，Wei 等人在《细胞代谢》中。 ¹揭示了一条从大脑到肠道的通路，该通路将心理压力传递给肠上皮细胞，导致其功能障碍。该肠-脑轴涉及微生物代谢物吲哚-3-乙酸酯 (IAA)，作为阻碍线粒体呼吸从而扭曲肠干细胞 (ISC) 命运的生态位信号。