A domino reaction featuring C−H activation and C−N coupling condenses ortho-fluorotoluenes and imines to give non fully aromatic indoline cores, that are not readily available by standard methods. Neither transition-metal-catalysts nor high pressure conditions are required for this straightforward, base-mediated synthesis.

中文翻译：

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通过碱介导的 CH 活化和脱氟 CN 偶联合成二氢吲哚，无需过渡金属


以 CH 活化和 CN 偶联为特征的多米诺骨牌反应会缩合邻氟甲苯和亚胺，得到非全芳香族二氢吲哚核心，而这通过标准方法不易获得。这种简单的、碱介导的合成既不需要过渡金属催化剂，也不需要高压条件。