The activation of ferroptosis is being pursued in cancer research as a strategy to target apoptosis-resistant cells. By contrast, in various diseases that affect the cardiovascular system, kidneys, liver, and central and peripheral nervous systems, attention is directed toward interventions that prevent ferroptotic cell death. Mechanistic insights into both research areas stem largely from studies using cellular models. However, intervention strategies that show promise in cellular test systems often fail in clinical trials, which raises concerns regarding the predictive validity of the utilized models.

中文翻译：

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人类多巴胺能神经元铁死亡模型：神经变性研究的陷阱和机遇

铁死亡的激活正在癌症研究中作为针对凋亡抗性细胞的策略。相比之下，在影响心血管系统、肾脏、肝脏以及中枢和周围神经系统的各种疾病中，人们的注意力集中在预防铁死亡细胞死亡的干预措施上。对这两个研究领域的机制见解很大程度上源于使用细胞模型的研究。然而，在细胞测试系统中显示出前景的干预策略常常在临床试验中失败，这引起了人们对所用模型的预测有效性的担忧。