Heart failure with preserved ejection fraction (HFpEF) presents a serious risk to human health. The increased prevalence of sarcopenia in the HFpEF population has a negative impact on patient prognosis. Uric acid (UA) is the byproduct of purine metabolism and is harmful to the cardiovascular system. This study aims to establish the potential relationship between sarcopenia and serum UA in HFpEF patients. Data were obtained from 180 individuals (aged ≥60 years) with HFpEF admitted to the Geriatric Department of Jiangsu Province Hospital between January 2021 and December 2022. The UA values were grouped into 4 quartiles (Q1-Q4). Logistic generalized linear models and restricted cubic spline (RCS) regression were used to analyze the relationship between sarcopenia and UA. Subgroups based on gender were utilised for further analysis. After adjusting for covariates, odds ratios (ORs) and 95 % confidence intervals (CIs) for sarcopenia prevalence in the 2nd, 3rd, and 4th quartiles were 2.56 (0.57–12.65), 4.94 (1.10–24.49), and 6.95 (1.30–44.25), respectively, unlike the 1st quartile (P for trend = 0.022). The RCS plot demonstrated a positive linear relationship between serum UA levels and sarcopenia (P for non-linearity = 0.190). A sex-based subgroup analysis revealed a statistically significant relationship between UA and sarcopenia in males ( < 0.05). In summary, the prevalence of sarcopenia is positively related to serum UA levels among the elderly diagnosed with HFpEF. Due to the cross-sectional nature of the study design, additional investigations are necessary to validate our findings and identify the optimal range for UA reduction.

中文翻译：

---

射血分数保留的老年心力衰竭患者血尿酸与肌少症的关系


射血分数保留的心力衰竭（HFpEF）对人类健康构成严重风险。 HFpEF 人群中肌肉减少症患病率的增加对患者预后产生负面影响。尿酸（UA）是嘌呤代谢的副产物，对心血管系统有害。本研究旨在建立 HFpEF 患者肌肉减少症与血清 UA 之间的潜在关系。数据来自 2021 年 1 月至 2022 年 12 月期间江苏省医院老年科收治的 180 名 HFpEF 患者（年龄≥60 岁）。UA 值分为 4 个四分位数（Q1-Q4）。采用Logistic广义线性模型和限制三次样条（RCS）回归分析肌少症与UA之间的关系。基于性别的亚组用于进一步分析。调整协变量后，第二、第三和第四四分位数肌肉减少症患病率的比值比 (OR) 和 95% 置信区间 (CI) 分别为 2.56 (0.57–12.65)、4.94 (1.10–24.49) 和 6.95 (1.30– 44.25），分别与第一个四分位数（趋势 P = 0.022）不同。 RCS 图显示血清 UA 水平与肌肉减少症之间呈正线性关系（非线性 P = 0.190）。基于性别的亚组分析显示，男性 UA 与肌肉减少症之间存在统计显着关系 (< 0.05)。综上所述，HFpEF老年人肌少症的患病率与血清UA水平呈正相关。由于研究设计的横截面性质，需要进行额外的调查来验证我们的研究结果并确定 UA 减少的最佳范围。