The objective of the study was to systematically investigate the association between gut microbiota (GM) abundance and Parkinson's disease (PD). PubMed, Medline, Cochrane Library and other literature datebase platforms were searched for eligible studies in the English-language from conception to March 1, 2024. Studies evaluating the association between GM and PD were included. The results of the included studies were analyzed using a random effects model with calculation of the mean difference (MD) with the 95 % confidence interval to quantify the incidence of differences in abundance of various bacterial families in PD patients. Continuous models were used to analyze the extracted data. A total of 14 studies with 1045 PD cases and 821 healthy controls were included for data extraction and meta-analysis. All the included studies exhibited reasonable quality. The included studies reported the data on the ratios of 10 families of GM. Of these 10 microbiota families, , , , , and were found to have increased ratios according to the pooled ratios, while , , and were decreased in PD cases. Patients in the PD cohort exhibited distinctive microbiota compositions compared to healthy individuals, with unique differential patterns in gut microbiome abundance at the phylum, family, and genus levels that may be associated wtih PD pathogenesis.

中文翻译：

---

肠道微生物群丰度增加和减少与帕金森病之间的关联：系统评价和亚组荟萃分析


该研究的目的是系统地研究肠道微生物群（GM）丰度与帕金森病（PD）之间的关联。检索了 PubMed、Medline、Cochrane 图书馆和其他文献数据库平台，寻找从受孕到 2024 年 3 月 1 日的合格英文研究。评估 GM 和 PD 之间关联的研究也被纳入其中。使用随机效应模型分析纳入研究的结果，并计算平均差 (MD) 和 95% 置信区间，以量化 PD 患者中各种细菌家族丰度差异的发生率。使用连续模型来分析提取的数据。共纳入 14 项研究，涉及 1045 名 PD 病例和 821 名健康对照者，进行数据提取和荟萃分析。所有纳入的研究均表现出合理的质量。纳入的研究报告了 10 个转基因家族的比率数据。在这 10 个微生物家族中，根据汇总比率， 、 、 、 和 的比率有所增加，而在 PD 病例中 、 、 和 的比率有所减少。与健康个体相比，PD 队列中的患者表现出独特的微生物群组成，在门、科和属水平上肠道微生物组丰度具有独特的差异模式，这可能与 PD 发病机制相关。