Hallucinations are a common feature of psychosis, yet access to effective psychological treatment is limited. The Managing Unusual Sensory Experiences for First-Episode-Psychosis (MUSE-FEP) trial aimed to establish the feasibility and acceptability of a brief, hallucination-specific, digitally provided treatment, delivered by a non-specialist workforce for people with psychosis. MUSE uses psychoeducation about the causal mechanisms of hallucinations and tailored interventions to help a person understand and manage their experiences. We undertook a two-site, single-blind (rater) Randomised Controlled Trial and recruited 82 participants who were allocated 1:1 to MUSE and treatment as usual (TAU) (n = 40) or TAU alone (n = 42). Participants completed assessments before and after treatment (2 months), and at follow up (3–4 months). Information on recruitment rates, adherence, and completion of outcome assessments was collected. Analyses focussed on feasibility outcomes and initial estimates of intervention effects to inform a future trial. The trial is registered with the ISRCTN registry 16793301. Criteria for the feasibility of trial methodology and intervention delivery were met. The trial exceeded the recruitment target, had high retention rates (87.8%) at end of treatment, and at follow up (86.6%), with good acceptability of treatment. There were 3 serious adverse events in the therapy group, and 5 in the TAU group. Improvements were evident in both groups at the end of treatment and follow up, with a particular benefit in perceived recovery in the MUSE group. We showed it was feasible to increase access to psychological intervention but a definitive trial requires further changes to the trial design or treatment.

中文翻译：

---

新颖、简短的心理疗法（管理不寻常的感官体验）对首发精神病幻觉的效果（MUSE FEP）：一项探索性随机对照试验的结果


幻觉是精神病的一个常见特征，但获得有效心理治疗的机会却很有限。管理首发精神病的异常感官体验 (MUSE-FEP) 试验旨在确定由非专业人员为精神病患者提供的简短、针对幻觉的数字化治疗的可行性和可接受性。 MUSE 利用有关幻觉因果机制的心理教育和量身定制的干预措施来帮助人们理解和管理他们的经历。我们进行了一项两中心、单盲（评估者）随机对照试验，招募了 82 名参与者，他们按照 1:1 的比例分配到 MUSE 组并照常治疗 (TAU) (n = 40) 或单独 TAU (n = 42)。参与者在治疗前、治疗后（2 个月）以及随访时（3-4 个月）完成评估。收集了有关招募率、依从性和结果评估完成情况的信息。分析侧重于可行性结果和干预效果的初步估计，为未来的试验提供信息。该试验已在 ISRCTN 登记处注册，编号为 16793301。试验方法和干预实施的可行性标准均得到满足。该试验超出了招募目标，治疗结束时和随访时的保留率较高（87.8%）和随访时（86.6%），治疗可接受性良好。治疗组发生 3 例严重不良事件，TAU 组发生 5 例。在治疗结束和随访时，两组都有明显的改善，其中 MUSE 组的康复效果尤其明显。我们证明增加心理干预的机会是可行的，但最终的试验需要进一步改变试验设计或治疗。