Achieving <i>α</i>‐methylation of BODIPYs remains challenging due to the electron‐deficient property of α‐position of BODIPYs. Herein, a H2O2/DMSO‐promoted radical process was employed, providing an approach for the construction of a series of α‐methyl and <i>α</i>,<i>α</i>‐dimethyl BODIPYs in 57‐68% yields. In addition, representative transformations and half‐gram experiments as well as their photophysical properties were studied to examine the potential applications.

中文翻译：

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通过 H2O2/DMSO 促进的直接甲基化实现 α-甲基 BODIPY 的区域选择性合成

由于 BODIPY α 位的缺电子特性，实现 BODIPY 的 <i>α</i>-甲基化仍然具有挑战性。在此，采用了 H2O2/DMSO 促进的自由基过程，为在 57- 中构建一系列 α-甲基和 <i>α</i>,<i>α</i>-二甲基 BODIPY 提供了一种方法。 68% 的收益率。此外，还研究了代表性变换和半克实验及其光物理性质，以检验潜在的应用。