The outbreak and rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have led to one of the most serious public health crises since the beginning of the 21st century. An oral anti-SARS-CoV-2 drug ensitrelvir was developed with satisfactory antiviral effect and was synthesized via different strategies. This Review summarizes the advantages and disadvantages of the currently reported synthetic strategies for ensitrelvir along with three related key building blocks derivatives from the view of procedure, yield, impurities, safety, and environment. This will provide a novel perspective for further process development and drug discovery.

中文翻译：

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抗 SARS-CoV-2 药物 Ensitrelvir 合成策略的全面综述

严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的爆发和迅速传播导致了21世纪初以来最严重的公共卫生危机之一。开发了一种口服抗 SARS-CoV-2 药物 enitrelvir，具有令人满意的抗病毒效果，并通过不同策略合成。本综述从程序、收率、杂质、安全性和环境的角度总结了目前报道的恩西瑞韦以及三个相关关键构件衍生物的合成策略的优缺点。这将为进一步的工艺开发和药物发现提供新的视角。