Synthesis, characterization and α-glucosidase inhibitory activity of fourteen derivatives (2 a–2 n) are reported in the current work. Seven derivatives exhibited notable inhibition with IC₅₀ values ranging from 5.67±0.89 μM to 17.87±2.39 μM in comparison with acarbose. Density functional theory (DFT) calculation was carried out to check electronic, structural, and spectroscopic properties of the compounds, while the significant binding affinity to the active site of glucosidase was confirmed through molecular docking studies.

中文翻译：

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氟比洛芬酰胺衍生物的合成作为糖尿病治疗的潜在先导：体外 α-葡萄糖苷酶抑制、分子对接和 DFT 模拟方法

 目前的工作报告了14 种衍生物 ( 2a  – 2n )的合成、表征和 α-葡萄糖苷酶抑制活性。与阿卡波糖相比，七种衍生物表现出显着的抑制作用，IC ₅₀值范围为5.67±0.89 μM至17.87±2.39 μM。通过密度泛函理论（DFT）计算来检查化合物的电子、结构和光谱性质，同时通过分子对接研究证实了与葡萄糖苷酶活性位点的显着结合亲和力。