The front cover picture illustrates the cooperative action of carboxylic acids in ruthenium-catalysed C−H oxygenation. Dicarboxylic acids, such as maleic acid, dramatically increase the basicity and electrophilicity of metal(oxo) intermediates through intramolecular electrostatic interactions. The ruthenium catalyst system, which incorporates the cooperative action of carboxylic acids, has become a powerful C−H oxidation method that offers both reactivity and site-selectivity. It progresses with site- and chemo-selectivity in the C−H oxidation using hydrogen peroxide as a terminal oxidant, even in multifunctionalized complex natural products. Details can be found in the Communication by Tatsuya Uchida and co-workers (D. Doiuchi, N. Shimoda, K. Okazaki, T. Uchida, Adv. Synth. Catal. 2024, 366, 2026–2034; DOI: 10.1002/adsc.202301453)

中文翻译：

---

封面图片：酸合作过渡金属催化氧原子转移：钌催化 C−H 氧化（Adv. Synth. Catal. 9/2024）


封面图片说明了钌催化的 C−H 氧化中羧酸的协同作用。二羧酸，例如马来酸，通过分子内静电相互作用显着增加金属（氧）中间体的碱性和亲电性。钌催化剂体系结合了羧酸的协同作用，已成为一种强大的 C−H 氧化方法，具有反应活性和位点选择性。它在使用过氧化氢作为末端氧化剂的 C−H 氧化中具有位点选择性和化学选择性，甚至在多功能化的复杂天然产物中也是如此。详细信息请参阅 Tatsuya Uchida 及其同事的通讯 (D. Doiuchi, N. Shimoda, K. Okazaki, T. Uchida, Adv. Synth. Catal. 2024, 366, 2026–2034; DOI: 10.1002/adsc .202301453)