Complete cardiac regeneration remains an elusive therapeutic goal. Although much attention has been focused on cardiomyocyte proliferation, especially in neonatal mammals, recent investigations have unearthed mechanisms by which non-cardiomyocytes, such as endothelial cells, fibroblasts, macrophages, and other immune cells, play critical roles in modulating the regenerative capacity of the injured heart. The degree to which each of these cell types influence cardiac regeneration, however, remains incompletely understood. This review highlights the roles of these non-cardiomyocytes and their respective contributions to cardiac regeneration, with emphasis on natural heart regeneration after cardiac injury during the neonatal period.

完整的心脏再生仍然是一个难以捉摸的治疗目标。尽管人们对心肌细胞增殖（尤其是新生哺乳动物）的增殖给予了很多关注，但最近的研究揭示了非心肌细胞（如内皮细胞、成纤维细胞、巨噬细胞和其他免疫细胞）在调节心肌细胞再生能力方面发挥关键作用的机制。受伤的心。然而，每种细胞类型影响心脏再生的程度仍不完全清楚。本综述强调了这些非心肌细胞的作用及其各自对心脏再生的贡献，重点关注新生儿期心脏损伤后的自然心脏再生。