Caged gem-dithiols have been developed as the donors of reactive sulfur species (RSS), but the chemistry of free gem-dithiols as RSS donors has not been well understood. Herein, we report the study of a free gem-dithiol, 1,3-diphenylpropane-2,2-dithiol, as the precursor for several RSS. It releases H₂S under physiological conditions and can be converted to a mono-S-nitrosothiol, which serves as a NO donor. Furthermore, it can be converted to 3,3-dibenzyldithiirane, which is an active sulfur transfer reagent and can induce S-persulfidation.

中文翻译：

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活性硫物质的偕二硫醇前体

笼状宝石二硫醇已被开发为活性​​硫物质(RSS)的供体，但游离宝石二硫醇作为RSS供体的化学性质尚未得到充分了解。在此，我们报告了对游离宝石二硫醇 1,3-二苯基丙烷-2,2-二硫醇作为几种 RSS 前体的研究。它在生理条件下释放H ₂ S，并可转化为单-S-亚硝基硫醇，作为NO供体。此外，它可以转化为3,3-二苄基二硫杂丙环，这是一种活性硫转移试剂，可以诱导S-过硫化。