Anomalous origin of the right coronary artery from the left sinus of Valsalva (R-ACAOS) is a relatively rare condition that can potentially lead to devastating outcomes. The current study aims to investigate the cardiac-related disorders among patients with incidental R-ACAOS diagnosis through computed tomography angiography (CTA). The current cross-sectional study has been conducted on 50 patients diagnosed with R-ACAOS who underwent CTA. Based on CTA, the patients' were categorized as R-ACAOS with interarterial course and non-interarterial course. The demographic and medical characteristics, any history of cardiac intervention and New York Heart Association (NYHA) Functional Classification at the time of diagnosis were recruited. Patients were revisited to assess cardiac-associated variables, including symptoms, the presence of heart failure and current NYHA function class. The variables including the history of cardiac intervention (-value<0.001), the presence of heart failure (-value = 0.010) and NYHA function class at the time of diagnosis (P-value = 0.006) were remarkably higher among those with interarterial course of R-ACAOS; while, the other variables including chest pain at rest (-value = 0.55) or on exertion (P-value = 0.12), current NYHA function class, current cardiac-associated symptoms except for dyspnea at rest (-value = 0.012), mortality and coronary calium score did not differ (P-value>0.05). coronary interventions led to significantly improved NYHA function class (P-value<0.05). Based on the findings of the current study, R-ACAOS with interarterial course leads to significantly higher rates of atherosclerotic-related symptoms and events compared with the other types of RCA anomalies. Moreover, coronary interventions led to significantly improved NYHA functional class regardless of R-ACAOS category.

中文翻译：

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误诊右冠状动脉左瓦尔萨尔瓦窦异常起源50例报告

右冠状动脉异常起源于左瓦尔萨尔瓦窦 (R-ACAOS) 是一种相对罕见的疾病，可能会导致毁灭性的后果。本研究旨在通过计算机断层扫描血管造影 (CTA) 调查偶然诊断出 R-ACAOS 的患者的心脏相关疾病。目前的横断面研究是对 50 名诊断为 R-ACAOS 并接受 CTA 的患者进行的。根据CTA，将患者分为动脉间病程和非动脉间病程的R-ACAOS。收集了诊断时的人口统计学和医学特征、任何心脏介入史以及纽约心脏协会 (NYHA) 功能分类。对患者进行重新随访以评估心脏相关变量，包括症状、心力衰竭的存在和当前的 NYHA 功能分级。包括心脏介入史（-值<0.001）、心力衰竭（-值= 0.010）和诊断时NYHA功能分级（P值= 0.006）在内的变量在动脉间病程患者中显着较高R-ACAOS；同时，其他变量包括静息时胸痛（-值 = 0.55）或劳力时胸痛（P 值 = 0.12）、当前 NYHA 功能分级、当前心脏相关症状（静息时呼吸困难除外）（-值 = 0.012）、死亡率和冠状动脉钙评分没有差异（P值> 0.05）。冠状动脉介入治疗导致 NYHA 功能等级显着改善（P 值<0.05）。根据当前研究的结果，与其他类型的 RCA 异常相比，具有动脉间病程的 R-ACAOS 导致动脉粥样硬化相关症状和事件的发生率显着更高。此外，无论 R-ACAOS 类别如何，冠状动脉介入治疗都能显着改善 NYHA 功能分级。