() is a common seafood-borne pathogen that can colonize the intestine of host and cause gastroenteritis. Biofilm formation by enhances its persistence in various environments, which poses a series of threats to food safety. This work aims to investigate the function of gene in biofilm formation and virulence of . Deletion of significantly reduced motility, biofilm biomass, and extracellular polymeric substances, and inhibited biofilm formation on a variety of food and food contact surfaces. In mice infection model, mice infected with ∆ strain exhibited a decreased rate of pathogen colonization, a lower level of inflammatory cytokines, and less tissue damage when compared to mice infected with wild type strain. RNA-seq analysis revealed that 374 genes were differentially expressed in the deletion mutant, which include genes related to quorum sensing, flagellar system, ribosome, type VI secretion system, biotin metabolism and transcriptional regulation. In conclusion, plays a role in determining biofilm formation and virulence of and further research is necessitated to fully understand its function in

中文翻译：

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rcpA基因在副溶血弧菌生物膜形成和毒力调控中的作用

()是一种常见的海鲜传播病原体，可定植于宿主肠道并引起胃肠炎。生物膜的形成增强了其在各种环境中的持久性，对食品安全构成了一系列威胁。本工作旨在研究基因在生物膜形成和毒力中的功能。删除显着降低的运动性、生物膜生物量和细胞外聚合物，并抑制各种食品和食品接触表面上的生物膜形成。在小鼠感染模型中，与野生型菌株感染的小鼠相比，Δ菌株感染的小鼠表现出病原体定植率降低、炎症细胞因子水平较低以及组织损伤较少。 RNA-seq分析显示，该缺失突变体中有374个基因存在差异表达，其中包括群体感应、鞭毛系统、核糖体、VI型分泌系统、生物素代谢和转录调控等相关基因。总之，在决定生物膜形成和毒力方面发挥着作用，需要进一步研究以充分了解其在