The American lobster, Homarus americanus, is not only of considerable economic importance but has also emerged as a premier model organism in neuroscience research. Neuropeptides, an important class of cell-to-cell signaling molecules, play crucial roles in a wide array of physiological and psychological processes. Leveraging the recently sequenced high-quality draft genome of the American lobster, our study sought to profile the neuropeptidome of this model organism. Employing advanced mass spectrometry techniques, we identified 24 neuropeptide precursors and 101 unique mature neuropeptides in Homarus americanus. Intriguingly, 67 of these neuropeptides were discovered for the first time. Our findings provide a comprehensive overview of the peptidomic attributes of the lobster’s nervous system and highlight the tissue-specific distribution of these neuropeptides. Collectively, this research not only enriches our understanding of the neuronal complexities of the American lobster but also lays a foundation for future investigations into the functional roles that these peptides play in crustacean species. The mass spectrometry data have been deposited in the PRIDE repository with the identifier PXD047230.

中文翻译：

---

美洲龙虾的神经肽组学

美洲龙虾（Homarus americanus）不仅具有相当大的经济重要性，而且已成为神经科学研究中首要的模式生物。神经肽是一类重要的细胞间信号分子，在广泛的生理和心理过程中发挥着至关重要的作用。利用最近测序的美国龙虾的高质量基因组草图，我们的研究试图描绘这种模式生物的神经肽组。采用先进的质谱技术，我们在美洲白鹤中鉴定出了 24 种神经肽前体和 101 种独特的成熟神经肽。有趣的是，其中 67 种神经肽是首次发现。我们的研究结果全面概述了龙虾神经系统的肽组属性，并强调了这些神经肽的组织特异性分布。总的来说，这项研究不仅丰富了我们对美洲龙虾神经元复杂性的理解，而且为未来研究这些肽在甲壳类动物中发挥的功能作用奠定了基础。质谱数据已存放在 PRIDE 存储库中，标识符为 PXD047230。