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Electrocatalytic conversion of ω-azido carboxylic acids to 1-pyrrolines via a combined process of oxidative decarboxylation and intramolecular Schmidt rearrangement
Organic Chemistry Frontiers ( IF 5.4 ) Pub Date : 2024-04-27 , DOI: 10.1039/d4qo00273c
Kai Yang 1 , Rui Li 1 , Peiming Gu 1
Affiliation  

1-Pyrrolines constitute a significant group of organic intermediates, and we present here an electrocatalytic method for their synthesis. Electrochemical oxidation of ω-azido carboxylic acids followed by an intramolecular Schmidt reaction was explored, and 26 1-pyrrolines were produced in up to 93% yield under an air atmosphere and in an undivided cell, where no external oxidants or catalysts were employed.

中文翻译:

通过氧化脱羧和分子内施密特重排的组合过程将 ω-叠氮基羧酸电催化转化为 1-吡咯啉

1-吡咯啉构成了一组重要的有机中间体,我们在这里提出了一种用于合成它们的电催化方法。研究人员探索了 ω-叠氮基羧酸的电化学氧化,然后进行分子内施密特反应,在空气气氛下和在不使用外部氧化剂或催化剂的未分隔电池中以高达 93% 的产率生成了 26 个 1-吡咯啉。
更新日期:2024-05-02
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