Porous organic frameworks (POFs) represent a significant subclass of nanoporous materials in the field of materials science, offering exceptional characteristics for advanced applications. Covalent organic frameworks (COFs), as a novel and intriguing type of porous material, have garnered considerable attention due to their unique design capabilities, diverse nature, and wide‐ranging applications. The unique structural features of COFs, such as high surface area, tuneable pore size, and chemical stability, render them highly attractive for various applications, including targeted and controlled drug release, as well as improving the sensitivity and selectivity of electrochemical biosensors. Therefore, it is crucial to comprehend the methods employed in creating COFs with specific properties that can be effectively utilized in biomedical applications. To address this indispensable fact, this review paper commences with a concise summary of the different methods and classifications utilized in synthesizing COFs. Second, it highlights the recent advancements in COFs for drug delivery, including drug carriers as well as the classification of drug delivery systems and biosensing, encompassing drugs, biomacromolecules, small biomolecules and the detection of biomarkers. While exploring the potential of COFs in the biomedical field, it is important to acknowledge the limitations that researchers may encounter, which could impact the practicality of their applications. Third, this paper concludes with a thought‐provoking discussion that thoroughly addresses the challenges and opportunities associated with leveraging COFs for biomedical applications. This review paper aims to contribute to the scientific community's understanding of the immense potential of COFs in improving drug delivery systems and enhancing the performance of biosensors in biomedical applications.

中文翻译：

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共价有机框架（COF）作为改进药物输送和生物传感应用的载体

多孔有机框架（POF）代表了材料科学领域纳米多孔材料的一个重要子类，为先进应用提供了卓越的特性。共价有机框架（COF）作为一种新颖而有趣的多孔材料，由于其独特的设计能力、多样化的性质和广泛的应用而引起了广泛的关注。 COF 独特的结构特征，例如高表面积、可调孔径和化学稳定性，使其对各种应用极具吸引力，包括靶向和受控药物释放，以及提高电化学生物传感器的灵敏度和选择性。因此，理解用于创建具有特定属性的COFs的方法至关重要，这些COFs可以有效地用于生物医学应用。为了解决这个不可或缺的事实，本文首先对合成 COF 中使用的不同方法和分类进行了简要总结。其次，它强调了COF在药物递送方面的最新进展，包括药物载体以及药物递送系统和生物传感的分类，包括药物、生物大分子、生物小分子和生物标志物的检测。在探索 COF 在生物医学领域的潜力时，重要的是要认识到研究人员可能遇到的局限性，这可能会影响其应用的实用性。第三，本文最后进行了一次发人深省的讨论，彻底解决了利用 COF 进行生物医学应用所面临的挑战和机遇。这篇综述论文旨在帮助科学界了解 COF 在改善药物输送系统和提高生物医学应用中生物传感器性能方面的巨大潜力。