In recent years, the use of organic small-molecule photosensitizers, which make up the majority of photosensitizers, has significantly enhanced the therapeutic outcomes of various diseases including cancer and antibacterial treatment because of their benefits of biocompatibility, minimal invasiveness, minimal toxicity, non-drug-resistance, and facile molecular tailoring. However, many organic small-molecule photosensitizers suffer from poor photostability, targeting, and controllability, which limit the bench-to-bedside transformation. Self-assembly strategies could effectively handle these problems and difficulties. This review provides an overview of the self-assembly strategies of organic small-molecule photosensitizers for photodynamic therapy in recent years, including molecular design and modification, stimuli-responsive, photosensitizer-drug conjugate, metal coordination, and others. The article also discussed the prospects and challenges of organic small-molecule photosensitizers in clinical applications.

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用于光动力治疗的有机小分子光敏剂的自组装策略

近年来，有机小分子光敏剂以其生物相容性、微创、低毒、无毒等优点，在光敏剂中占大多数，其使用显着提高了包括癌症和抗菌治疗在内的多种疾病的治疗效果。耐药性和简单的分子剪裁。然而，许多有机小分子光敏剂的光稳定性、靶向性和可控性较差，限制了其向临床的转化。自组装策略可以有效解决这些问题和困难。本文综述了近年来用于光动力治疗的有机小分子光敏剂的自组装策略，包括分子设计和修饰、刺激响应、光敏剂-药物偶联、金属配位等。文章还讨论了有机小分子光敏剂在临床应用中的前景和挑战。