Stimuli-responsive drug delivery systems exhibit dynamic responses to pH, enzyme, redox, magnetic, thermal, and light stimuli through reversible coordination bonds with metal ions (e.g. Zn, Cu, Fe/Fe) and ligands such as ethylenediamine tetraacetic acid and azobenzene. Overcoming the limitations like uncontrolled release and degradation, coordination bonds offer tunability and dynamic responses for tailored drug delivery with a bond strength of 25–95 % of covalent bond. Metal organic frameworks (MOFs) utilize electrostatic interactions to demonstrate controlled drug release with significant adaptability and multifunctionality in pharmaceutical nanocarrier systems. Notably, MOFs like Fe-BTC and Zn-BTC exhibited higher drug-loading efficiencies of maximum 83 % and 92 %, respectively. Coordination polymers and MOFs with lanthanides explore the applications from self-healing materials to anticancer-metallogels. Metal-liganded bioactives (including iron-sulfur coordination complexes) enable controlled release of drug in response to stimuli like pH and ion activation. Mesoporous materials offer biocompatibility with better drug delivery efficiency, mainly for BCS class II and IV drugs. Supramolecular coordination complexes and coordination polymer networks with their high surface areas and pH-responsiveness behaviours explore tailored drug release profile. In liver cancer therapy, supramolecular assemblies demonstrated controlled drug release in response to stimuli of tumor microenvironment. pH/ROS-responsive nanoparticles showed a remarkable reduction in pro-inflammatory cytokines, primarily IL-6, reduced by 120-times. These advancements underscore the potential of coordination bond for enhancing the efficacy of drug in delivery system. The review article highlights the promise of metal–ligand interactions in drug design as well as emphasizes on the advancement of metal-coordinating drugs for approaching various pharmaceutical applications in the management and treatment of cancer, arthritis and inflammation.

中文翻译：

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化学活性物质与金属的配位键合刺激响应药物递送系统在制药应用中的应用

刺激响应性药物递送系统通过与金属离子（例如Zn、Cu、Fe/Fe）和配体（例如乙二胺四乙酸和偶氮苯）的可逆配位键，对pH、酶、氧化还原、磁、热和光刺激表现出动态响应。配位键克服了不受控释放和降解等限制，为定制药物输送提供了可调性和动态响应，键强度为共价键的 25-95%。金属有机框架（MOF）利用静电相互作用来证明药物纳米载体系统中的受控药物释放具有显着的适应性和多功能性。值得注意的是，Fe-BTC 和 Zn-BTC 等 MOF 表现出较高的载药效率，分别最高为 83% 和 92%。配位聚合物和含有镧系元素的 MOF 探索了从自修复材料到抗癌金属凝胶的应用。金属配体生物活性物质（包括铁硫配位络合物）能够响应 pH 值和离子激活等刺激来控制药物释放。介孔材料具有生物相容性和更好的药物递送效率，主要用于BCS II类和IV类药物。超分子配位络合物和配位聚合物网络具有高表面积和 pH 响应行为，可探索定制的药物释放曲线。在肝癌治疗中，超分子组件表现出响应肿瘤微环境刺激的受控药物释放。 pH/ROS 响应纳米颗粒显示促炎细胞因子显着减少，主要是 IL-6，减少了 120 倍。这些进展强调了配位键在增强药物递送系统功效方面的潜力。这篇综述文章强调了金属-配体相互作用在药物设计中的前景，并强调了金属配位药物在癌症、关节炎和炎症的管理和治疗中的各种药物应用的进展。