Surface-enhanced Raman scattering (SERS) technique is a powerful assay due to its high sensitivity, rapid detection, and fingerprint vibration specificity. Magnetic nanoparticle composite-based SERS strategy presents additional merits of easy magnetic enrichment of sample, detection selectivity improved via magnetic separation and excellent sensitivity reached by magnetic inducing optimization of localized surface plasmon resonance fields to generate more hot spots. In this review, we introduce the preparation and classification of magnetic SERS substrates, surface functionalization strategies, the mechanism of magnetic inducing optimization SERS and then focus on their recent applications in the fields of food safety inspection, biomedical detection, and environmental analysis. As a perspective, metal salt-based spinel ferrites as promising strong magnetic substrates need to be concerned to advance magnetic optimization effect in SERS detection because of easy magnetic preparation, tolerance in chemical media, and the long-term stability during storage. Challenges and opportunities in magnetic substrate-based SERS assays are also discussed.

中文翻译：

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磁优化表面增强拉曼散射检测策略及其传感应用

表面增强拉曼散射 (SERS) 技术因其高灵敏度、快速检测和指纹振动特异性而成为一种强大的检测方法。基于磁性纳米粒子复合材料的SERS策略具有以下优点：样品易于磁富集、通过磁分离提高检测选择性以及通过局部表面等离子体共振场的磁诱导优化以产生更多热点而达到优异的灵敏度。在这篇综述中，我们介绍了磁性SERS基底的制备和分类、表面功能化策略、磁诱导优化SERS的机理，然后重点介绍了它们在食品安全检测、生物医学检测和环境分析等领域的最新应用。从长远来看，金属盐基尖晶石铁氧体作为有前景的强磁性基底，由于磁性制备简单、对化学介质的耐受性以及储存过程中的长期稳定性，需要关注以提高SERS检测中的磁优化效果。还讨论了基于磁性基质的 SERS 测定的挑战和机遇。