TiC MXene quantum dots (MQDs) have recently gained considerable attention as promising emerging nanomaterials for biosensing applications. However, it is still in the infancy of research on the functionalisation of MQDs to improve their properties. This work synthesised glutathione (GSH)-modified MQDs by hydrothermal method and functionalised them with porphyrin (TMPyP), resulting in porphyrin-functionalised GSH-TiC MXene quantum dots (MQDs-TMPyP) nanocomposite with enhanced electrochemiluminescence (ECL) properties. The lack of selectivity of MQDs and the weak luminescence intensity of ECL have been solved, expanding the method for developing materials with enhanced ECL properties. Cu was found to quench the ECL luminescence of MQDs-TMPyP, which is valuable for detecting copper ions. Consequently, we constructed a sensitive “Signal on–off” biosensor for Cu detection. The biosensor demonstrated a sensitive response to copper ions within the concentration range of 10 nM to 10 μM, with an impressively low detection limit of 3.22 nM. Additionally, the biosensor exhibited good stability and selectivity. The ECL biosensor performed well and provided an efficient and ultra-sensitive method for detecting Cu.

中文翻译：

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卟啉功能化谷胱甘肽-Ti3C2 MXene 量子点，用于增强电化学发光和铜离子的灵敏检测

TiC MXene 量子点 (MQD) 作为生物传感应用中前景广阔的新兴纳米材料，最近受到了广泛关注。然而，通过 MQD 功能化来改善其性能的研究仍处于起步阶段。这项工作通过水热法合成了谷胱甘肽（GSH）修饰的MQD，并用卟啉（TMPyP）对其进行功能化，产生了具有增强电化学发光（ECL）性能的卟啉功能化GSH-TiC MXene量子点（MQDs-TMPyP）纳米复合材料。 MQD选择性不足和ECL发光强度弱的问题得到了解决，拓展了开发具有增强ECL性能的材料的方法。研究发现 Cu 可以猝灭 MQDs-TMPyP 的 ECL 发光，这对于检测铜离子很有价值。因此，我们构建了一种用于铜检测的灵敏“信号开关”生物传感器。该生物传感器对 10 nM 至 10 μM 浓度范围内的铜离子表现出灵敏的响应，检测限低至 3.22 nM，令人印象深刻。此外，该生物传感器表现出良好的稳定性和选择性。 ECL生物传感器表现良好，为检测Cu提供了一种高效、超灵敏的方法。