The transient expression of CD61 and its unconventional pairing with CD103 at the immune synapse enhances T cell receptor signaling, improves anti-tumor cytotoxicity and mitigates tumor growth. Clinically, CD61+ tumor infiltrating lymphocytes (TILs) exhibit enhanced effector functions and show limited cellular exhaustion.

中文翻译：

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瞬时突触 CD61 与 CD103 配对可增加抗原特异性 T 细胞的细胞毒性

CD61 的瞬时表达及其在免疫突触处与 CD103 的非常规配对可增强 T 细胞受体信号传导，提高抗肿瘤细胞毒性并减轻肿瘤生长。临床上，CD61+肿瘤浸润淋巴细胞（TIL）表现出增强的效应功能和有限的细胞耗竭。