The main purpose of our studies is to demonstrate that commercially available mesoporous silica (MS) can be used to control the physical state of aripiprazole (ARP). The investigations performed utilizing differential scanning calorimetry and broadband dielectric spectroscopy reveal that silica can play different roles depending on its concentration in the system with amorphous ARP. At low MS content, it activates recrystallization of the active pharmaceutical ingredient and supports forming the III polymorphic form of ARP. At intermediate MS content (between ca. 27 and 65 wt %), MS works as a recrystallization inhibitor of ARP. At these concentrations, the formation of III polymorphic form is no longer favorable; therefore, it is possible to use this additive to obtain ARP in either IV or X polymorphic form. At the same time, employing MS in concentrations >65 wt % amorphous form of ARP with high physical stability can be obtained. Finally, regardless of the polymorphic form it crystallizes into, each composite is characterized by the same temperature dependence of relaxation times in the supercooled and glassy states.

中文翻译：

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通过介孔二氧化硅调节阿立哌唑的物理状态

我们研究的主要目的是证明市售介孔二氧化硅（MS）可用于控制阿立哌唑（ARP）的物理状态。利用差示扫描量热法和宽带介电光谱进行的研究表明，二氧化硅可以根据其在非晶态 ARP 系统中的浓度发挥不同的作用。 MS 含量低时，它会激活活性药物成分的重结晶并支持形成 ARP III 多晶型形式。当 MS 含量处于中等水平（约 27 至 65 wt% 之间）时，MS 可充当 ARP 的再结晶抑制剂。在这些浓度下，不再有利于III多晶型物的形成；因此，可以使用该添加剂获得 IV 或多晶型形式的 ARP。同时，采用MS，可以得到浓度>65wt%的具有高物理稳定性的无定形ARP。最后，无论其结晶成何种多晶型，每种复合材料都具有相同的过冷态和玻璃态弛豫时间的温度依赖性特征。