species are a normal human flora in humans' digestive and reproductive systems, oral cavity, skin, and mucosal surfaces. This study aimed to detect the immunological role of infection by using some immunological markers. The results of levels in serum showed high concentrations of IgA (56.20 ± 12 pg/ml,29.55 ± 4.5 pg/ml respectively) and IgG (12.05 ± 3.218 pg/ml, 3.836 ± 1.23 pg/ml respectively) in mice infected with and mice treated with Cefoperazone and infected with with significant differences (P value < 0.05). The results showed high serum levels of IL-17(191.5 ± 42.81 pg/ml) and TLR2(7.651 ± 1.5 pg/ml) in group mice infected with C. albicans compared with negative control and group mice treated with Cefoperazone. Also, high levels of IL-17 (91.33 ± 4.816 pg/ml) and TLR2 (2.630 ± 0.5 pg/ml) in group mice treated with Cefoperazone and infected with Candida compared with negative control and group mice treated with Cefoperazone (P value < 0.05). The results of antibodies and immunological markers in the intestine showed high levels of IgA and IgG in mice infected with (55.7 ± 4.9 pg/ml, 18.19 ± 0.63 pg/ml respectively).Also,IgA and IgG in mice treated with Cefoperazone and infected with were high level (43.04 ± 2.1 pg/ml, 2.927 ± 0.2 pg/ml respectively) in mice infected with with significant differences (P value < 0.05). The results levels of IL-17 and TLR2 were increased in mice infected with (191.5 ± 42.81 pg/ml, 7.651 ± 1.5 pg/ml respectively) and mice treated with Cefoperazone and infected with (91.33 ± 4.816 pg/ml,2.630 ± 0.5 pg/ml respectively) with significant differences (P < 0.05). In conclusion, this study demonstrated that cefoperazone treatment and infection by changed the microbiome components in the gut and finally can change host immune responses. It was observed that elevated levels of the antibodies production (IgA and IgG) and immunological markers (IL-17, and TLR2) in serum and the gut.

中文翻译：

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头孢哌酮治疗小鼠对白色念珠菌定植的免疫反应


物种是人类消化系统、生殖系统、口腔、皮肤和粘膜表面的正常人类菌群。本研究旨在通过使用一些免疫学标记物来检测感染的免疫学作用。血清水平结果显示，感染和感染小鼠的 IgA（分别为 56.20 ± 12 pg/ml、29.55 ± 4.5 pg/ml）和 IgG（分别为 12.05 ± 3.218 pg/ml、3.836 ± 1.23 pg/ml）浓度较高。用头孢哌酮治疗和感染的小鼠具有显着差异（P 值 < 0.05）。结果显示，与阴性对照组和头孢哌酮治疗组小鼠相比，白色念珠菌感染组小鼠血清中IL-17（191.5±42.81pg/ml）和TLR2（7.651±1.5pg/ml）水平较高。此外，与阴性对照组和头孢哌酮治疗组小鼠相比，用头孢哌酮治疗并感染念珠菌的小鼠组中 IL-17 (91.33 ± 4.816 pg/ml) 和 TLR2 (2.630 ± 0.5 pg/ml) 水平较高（P 值 < 0.05）。肠道内抗体和免疫标记物结果显示，感染小鼠的 IgA 和 IgG 水平较高（分别为 55.7 ± 4.9 pg/ml、18.19 ± 0.63 pg/ml）。此外，头孢哌酮治疗和感染的小鼠中 IgA 和 IgG 水平较高在感染小鼠中，其水平较高（分别为 43.04 ± 2.1 pg/ml、2.927 ± 0.2 pg/ml），差异显着（P 值 < 0.05）。结果感染小鼠（分别为 191.5 ± 42.81 pg/ml、7.651 ± 1.5 pg/ml）和用头孢哌酮治疗并感染（91.33 ± 4.816 pg/ml、2.630 ± 0.5）的小鼠中 IL-17 和 TLR2 水平升高。分别为 pg/ml），差异显着（P < 0.05）。总之，这项研究证明头孢哌酮治疗和感染通过改变肠道微生物组成分，最终可以改变宿主免疫反应。 据观察，血清和肠道中抗体产生（IgA 和 IgG）和免疫标记物（IL-17 和 TLR2）水平升高。