Doxorubicin (DOX) is an important drug for cancer treatment, but its clinical application is limited due to its toxicity and side effects. Therefore, detecting the concentration of DOX during treatment is crucial for enhancing efficacy and reducing side effects. In this study, the authors developed a biophotonic fiber sensor based on localized surface plasmon resonance (LSPR) with the multimode fiber (MMF)-four core fiber (FCF)-seven core fiber (SCF)-MMF-based direct-taper and anti-taper structures for the specific detection of DOX. Compared to other detection methods, it has the advantages of high sensitivity, low cost, and strong anti-interference ability. In this experiment, multi-walled carbon nanotubes (MWCNTs), cerium-oxide nanorods (CeO₂-NRs), and gold nanoparticles (AuNPs) were immobilized on the probe surface to enhance the sensor's biocompatibility. MWCNTs and CeO₂-NRs provided more binding sites for the fixation of AuNPs. By immobilizing AuNPs on the surface, the LSPR was stimulated by the evanescent field to detect DOX. The sensor surface was functionalized with DOX aptamers for specific detection, enhancing its specificity. The experiments demonstrated that within a linear detection range of 0-10 µM, the sensitivity of the sensor is 0.77 nm/µM, and the limit of detection (LoD) is 0.42 µM. Additionally, the probe's repeatability, reproducibility, stability, and selectivity were evaluated, indicating that the probe has high potential for detecting DOX during cancer treatment.

中文翻译：

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使用七芯和四芯光纤的直接锥度和反锥度技术开发生物光子光纤传感器，用于检测癌症治疗中的阿霉素

阿霉素（DOX）是治疗癌症的重要药物，但因其毒副作用而限制了其临床应用。因此，检测治疗过程中DOX的浓度对于提高疗效、减少副作用至关重要。在这项研究中，作者开发了一种基于局域表面等离子体共振（LSPR）的生物光子光纤传感器，采用多模光纤（MMF）-四芯光纤（FCF）-七芯光纤（SCF）-MMF为基础的直接锥度和反-用于特异性检测 DOX 的锥形结构。与其他检测方法相比，它具有灵敏度高、成本低、抗干扰能力强等优点。在该实验中，多壁碳纳米管（MWCNTs）、氧化铈纳米棒（CeO ₂ -NRs）和金纳米颗粒（AuNPs）被固定在探针表面以增强传感器的生物相容性。 MWCNTs和CeO ₂ -NRs为AuNPs的固定提供了更多的结合位点。通过将 AuNPs 固定在表面，局域表面等离子体共振 (LSPR) 受到倏逝场的刺激来检测 DOX。传感器表面用 DOX 适体进行功能化，用于特异性检测，增强其特异性。实验表明，在0-10 µM的线性检测范围内，传感器的灵敏度为0.77 nm/μM，检测限（LoD）为0.42 µM。此外，还对该探针的重复性、重现性、稳定性和选择性进行了评估，表明该探针在癌症治疗期间检测 DOX 具有很高的潜力。