Benastatin K (1), a new chlorinated benastatin derivative, was isolated from the culture broth of the actinomycete Streptomyces sp. HGTA384. The structure of 1 was determined on the basis of spectroscopic analysis, including 1D and 2D NMR, as well as HRESI-MS, UV and IR, and comparison with data reported in the literature. Compound 1 and benastatins A and B exhibited inhibitory activity against Micrococcus luteus (MIC 7.8, 31.3, and 3.9 μM, respectively), and IgE-mediated β-hexosaminidase release in RBL-2H3 cells with IC₅₀ values of 42, 79, and 19 μM, respectively.

中文翻译：

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Benastatin K，一种来自链霉菌属的氯化贝那他汀相关抗生素。 HGTA384

Benastatin K ( 1 ) 是一种新的氯化贝那他汀衍生物，是从放线菌链霉菌的培养液中分离出来的。 HGTA384。1的结构是在光谱分析的基础上确定的，包括一维和二维核磁共振，以及高分辨质谱、紫外和红外，并与文献报道的数据进行比较。化合物1和贝那他汀 A 和 B 对藤黄微球菌具有抑制活性（MIC 分别为 7.8、31.3 和 3.9 μM），并且在 RBL-2H3 细胞中表现出 IgE 介导的 β-己糖胺酶释放，IC ₅₀值为 42、79 和 19分别为μM。