Many cancer patients are at risk of developing cognitive symptoms that often become evident during or after cancer-directed therapy and may involve difficulties with attention, concentration, multitasking, executive function, and memory. Despite recent advances in identifying potential molecular and cellular mechanisms underlying cancer and chemotherapy-related cognitive impairment, there is generally a lack of effective treatment strategies, and the development of novel therapeutic interventions represents a major unmet medical need in clinical practice. A recent study by Kim and colleagues suggests that multi-sensory 40-Hz gamma entrainment using sensory stimuli (GENUS) with combined visual and auditory stimuli is associated with powerful neuroprotective effects in mouse models of cisplatin or methotrexate-induced ‘chemobrain’. While the study has some limitations and successful interventions in animal models have often failed to translate into clinical practice, this non-invasive treatment modality has promise to protect brain structure and function and could be tested in cancer patients who are at risk for cognitive decline.

中文翻译：

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探索化疗相关认知障碍的新治疗途径

许多癌症患者面临出现认知症状的风险，这些症状通常在癌症定向治疗期间或之后变得明显，并且可能涉及注意力、注意力、多任务处理、执行功能和记忆方面的困难。尽管最近在识别癌症和化疗相关认知障碍的潜在分子和细胞机制方面取得了进展，但普遍缺乏有效的治疗策略，并且新型治疗干预措施的开发代表了临床实践中未满足的主要医疗需求。 Kim 及其同事最近的一项研究表明，使用感觉刺激 (GENUS) 结合视觉和听觉刺激的多感觉 40-Hz 伽马夹带与顺铂或甲氨蝶呤诱导的“化学脑”小鼠模型中强大的神经保护作用相关。虽然该研究存在一些局限性，并且对动物模型的成功干预往往无法转化为临床实践，但这种非侵入性治疗方式有望保护大脑结构和功能，并且可以在有认知能力下降风险的癌症患者中进行测试。