Recent studies have indicated that clinical high risk for psychosis (CHR-P) is highly specific for psychotic disorders other than pluripotential to various serious mental illnesses. However, not all CHR-P develop psychotic disorder only, and psychosis can occur in non-psychotic disorders as well. Our prospective cohort study aims to investigate the characteristics and clinical outcomes of a pluripotent high-risk group with the potential to develop a diverse range of psychiatric disorders. The SPRIM study is a prospective naturalistic cohort program that focuses on the early detection of those at risk of developing serious mental illness, including psychosis (CHR-P), bipolar (CHR-B), and depressive disorder (CHR-D), as well as undifferentiated risk participants (UCHR). Our study has a longitudinal design with a baseline assessment and eight follow-up evaluations at 6, 12, 18, 24, 30, 36, 42, and 48 months to determine whether participants have transitioned to psychosis or mood disorders. The SPRIM sample consisted of 90 CHR participants. The total cumulative incidence rate of transition was 53.3% (95% CI 32.5–77.2). CHR-P, CHR-B, CHR-D, and UCHR had cumulative incidence rates of 13.7% (95% CI 3.4–46.4), 52.4% (95% CI 28.1–81.1), 66.7% (95% CI 24.6–98.6) and 54.3% (95% CI 20.5–93.1), respectively. The cumulative incidence of psychosis, bipolar, and depressive disorder among all participants was 3.3% (95% CI 0.8–11.5), 45.7% (95% CI 24.4–73.6), and 11.2% (95% CI 3.1–36.2), respectively. Our study suggests that the concept of pluripotent high-risk for a diverse range of psychiatric disorders is an integrative approach to examining transdiagnostic interactions between illnesses with a high transition rate and minimizing stigma.

中文翻译：

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可能发展为多种精神疾病的多能高危人群的特征和临床结果


最近的研究表明，临床精神病高风险（CHR-P）对于精神障碍具有高度特异性，而不是对各种严重精神疾病的多能性。然而，并非所有 CHR-P 都只发展为精神障碍，非精神障碍也可能发生精神病。我们的前瞻性队列研究旨在调查可能发展为多种精神疾病的多能高危人群的特征和临床结果。 SPRIM 研究是一项前瞻性自然队列计划，重点是早期发现那些有患严重精神疾病风险的人，包括精神病 (CHR-P)、躁郁症 (CHR-B) 和抑郁症 (CHR-D)，如以及无差别风险参与者 (UCHR)。我们的研究采用纵向设计，包括基线评估和 6、12、18、24、30、36、42 和 48 个月的八次随访评估，以确定参与者是否已转变为精神病或情绪障碍。 SPRIM 样本由 90 名 CHR 参与者组成。总累积转变发生率为 53.3% (95% CI 32.5–77.2)。 CHR-P、CHR-B、CHR-D 和 UCHR 的累积发病率为 13.7% (95% CI 3.4–46.4)、52.4% (95% CI 28.1–81.1)、66.7% (95% CI 24.6–98.6) ）和 54.3%（95% CI 20.5–93.1）。所有参与者中精神病、躁郁症和抑郁症的累积发生率分别为 3.3% (95% CI 0.8–11.5)、45.7% (95% CI 24.4–73.6) 和 11.2% (95% CI 3.1–36.2) 。我们的研究表明，多种精神疾病的多能高风险概念是一种综合方法，用于检查高转移率疾病之间的跨诊断相互作用并最大限度地减少耻辱感。