The targeted removal of Aβ accumulation emerges as a promising strategy for Alzheimer's disease (AD) treatment, offering potential avenues for the development of innovative anti-AD therapeutics. In this study, the effect of curcumin (Cur) with AD therapeutic potential on the cellular mechanical properties of Aβ fibril-induced neurons injury in the hippocampus of mice has been explored. The results showed that Cur had no obvious toxicity and side effects on neuronal cells and could significantly inhibit Aβ-induced cell damage and improve cell survival. The measurements of cell mechanical properties revealed that Cur could restore the mechanical properties of damaged cells to a large extent. In addition, the inhibition mechanism of Cur on Aβ-induced damage cell model was explained, which provides clues for the development of new drugs for the AD treatment.

中文翻译：

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姜黄素减轻 Aβ33-42 原纤维诱导的海马神经元损伤

靶向去除 Aβ 积累成为阿尔茨海默病 (AD) 治疗的一种有前途的策略，为开发创新的抗 AD 疗法提供了潜在途径。在本研究中，探讨了具有 AD 治疗潜力的姜黄素 (Cur) 对 Aβ 原纤维诱导的小鼠海马神经元损伤的细胞力学特性的影响。结果表明，Cur对神经元细胞无明显毒副作用，能显着抑制Aβ诱导的细胞损伤，提高细胞存活率。细胞机械性能的测量表明，Cur可以在很大程度上恢复受损细胞的机械性能。此外，还解释了Cur对Aβ诱导的损伤细胞模型的抑制机制，为AD治疗新药的开发提供线索。