Since 2002, intensive research on glycerol polyester has been ongoing. Poly(glycerol sebacate) (PGS) is most often studied because of its high applicable potential in many medical uses. This polyester is commonly synthesised from glycerine and sebacic acid in a molar ratio G/SA = 1:1. Nowadays, synthesis and thermal crosslinking processes are very time-consuming. At least 24 h for each, sometimes even a few days. There is a lack of works comparing these processes with polymerisation theory, such as Carothers Equations or Flory-Stockmayer Theory. In this work, experiments were performed at characteristic points of molar ratio determined from mathematical modelling. Currently published syntheses and crosslinking processes are characterised by long times, probably due to the use of the wrong molar ratio of monomers. The most effective glycerine to sebacic acid ratio is 2:3, according to both theories. This parameter should be considered for further synthesis optimisation and scaling up. This is also important for industrial implementation due to economic and ecological aspects. Moreover, the study of the G/SA ratio outside the range of 0.5–1.0 has no theoretical and experimental justification.

中文翻译：

---

Carothers 和 Flory-Stockmayer 理论作为目前无效的聚癸二酸甘油酯合成和交联的新视角

自2002年以来，对甘油聚酯的深入研究一直在进行。聚癸二酸甘油酯 (PGS) 最常被研究，因为它在许多医疗用途中具有很高的应用潜力。这种聚酯通常由甘油和癸二酸以摩尔比 G/SA = 1:1 合成。如今，合成和热交联过程非常耗时。每次至少24小时，有时甚至几天。缺乏将这些过程与聚合理论（例如卡罗瑟方程或弗洛里-斯托克迈耶理论）进行比较的著作。在这项工作中，在通过数学模型确定的摩尔比的特征点进行了实验。目前发表的合成和交联过程的特点是时间长，可能是由于使用了错误的单体摩尔比。根据这两种理论，最有效的甘油与癸二酸的比例是 2:3。应考虑此参数以进行进一步的合成优化和放大。由于经济和生态方面的原因，这对于工业实施也很重要。此外，G/SA比在0.5-1.0范围之外的研究没有理论和实验依据。