Hereby, we describe the synthesis of a self-assembled syn-cryptophane using dynamic nucleophilic aromatic substitution of tetrazines. ¹H NMR cage titrations reveal that the tetramethylammonium cation binds under slow exchange conditions while counter-anions show a fast exchange regime. Finally, the cryptophane can be disassembled by the addition of thiols allowing guest release.

中文翻译：

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自组装四嗪加密烷用于离子对识别和通过笼拆卸释放客体

在此，我们描述了使用四嗪的动态亲核芳香取代来合成自组装顺式加密烷。¹ H NMR 笼式滴定表明，四甲基铵阳离子在慢速交换条件下结合，而反阴离子则显示出快速交换状态。最后，可以通过添加硫醇来分解 Cryptophane，从而释放客体。