Particles exhibiting a plate-like shape, encountered during crystallization, present challenges in downstream processing. Consequently, it is crucial to manipulate the size and shape of such populations. However, comprehensive studies addressing this issue are lacking due to the absence of monitoring tools capable of accurately characterizing the particle size and shape distribution (PSSD) systems with a complex morphology. Leveraging recent advancements in monitoring technology, this work investigates a multistage crystallization process, encompassing growth, wet milling, and dissolution, to modify the PSSD of plate-like crystals. Employing a combination of experimental and modeling approaches, with adipic acid in water as the system, the influence of key multistage process parameters on the PSSD and filtration performance is evaluated. A multidimensional population balance equation-based model is utilized to analyze the intricate interplay among growth, dissolution, and breakage kinetics. The findings demonstrate the efficacy of the multistage process in modifying the particle size and fines content and thereby reducing the filter cake resistance of the product, a key indicator of powder processability. The insights gained from this study will be instrumental in designing processes for manipulating the size and shape of crystalline powders, particularly exhibiting a complex morphology like the one studied here.

中文翻译：

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板状晶体的多级结晶：己二酸的模拟和实验研究

结晶过程中遇到的呈现板状形状的颗粒给下游加工带来了挑战。因此，控制这些种群的规模和形状至关重要。然而，由于缺乏能够准确表征具有复杂形态的颗粒尺寸和形状分布（PSSD）系统的监测工具，因此缺乏解决这一问题的综合研究。利用监测技术的最新进展，这项工作研究了多阶段结晶过程，包括生长、湿磨和溶解，以修改板状晶体的 PSSD。采用实验和建模相结合的方法，以水中己二酸为体系，评估了关键多级工艺参数对 PSSD 和过滤性能的影响。利用基于多维群体平衡方程的模型来分析生长、溶解和破碎动力学之间复杂的相互作用。研究结果证明了多级工艺在改变粒度和细粉含量方面的功效，从而降低了产品的滤饼阻力，这是粉末加工性能的关键指标。从这项研究中获得的见解将有助于设计控制结晶粉末的尺寸和形状的工艺，特别是表现出像这里研究的复杂形态。