In the United States, Asian and Pacific Islander (A/PI) communities have faced significant discrimination and stigma during the COVID-19 pandemic. We assessed the association between discrimination and depression, anxiety, and loneliness symptoms among Asian or Pacific Islander adults (n = 543) using data from a 116-item nationally distributed online survey of adults (≥ 18 years old) in the United States conducted between 5/2021–1/2022. Discrimination was assessed using the 5-item Everyday Discrimination Scale. Anxiety, depression, and loneliness symptoms were assessed using the 2-item Generalized Anxiety Disorder, 2-item Patient Health Questionnaire, and UCLA Loneliness Scale—Short form, respectively. We used multivariable logistic regression to estimate the association between discrimination and mental health. Overall, 42.7% of participants reported experiencing discrimination once a month or more. Compared with no discrimination, experiencing discrimination once a month was associated with increased odds of anxiety (Adjusted Odds Ratio [aOR] = 2.60, 95% CI = 1.38–4.77), depression (aOR = 2.58, 95% CI = 1.46–4.56), and loneliness (aOR = 2.86, 95% CI = 1.75–4.67). Experiencing discrimination once a week or more was associated with even higher odds of anxiety (aOR = 6.90, 95% CI = 3.71–12.83), depression, (aOR = 6.96, 95% CI = 3.80–12.74), and loneliness (aOR = 6.91, 95% CI = 3.38–13.00). Discrimination is detrimental to mental health, even at relatively low frequencies; however, more frequent discrimination was associated with worse mental health symptoms. Public health interventions and programs targeting anti-A/PI hate and reducing A/PI mental health burden are urgently needed.

在美国，亚裔和太平洋岛民 (A/PI) 社区在 COVID-19 大流行期间面临严重的歧视和耻辱。我们使用来自美国全国分布的 116 项成年人（≥ 18 岁）在线调查的数据，评估了亚裔或太平洋岛民成年人 (n = 543) 中歧视与抑郁、焦虑和孤独症状之间的关联。 5/2021–1/2022。使用 5 项日常歧视量表评估歧视情况。分别使用 2 项广泛性焦虑症、2 项患者健康问卷和 UCLA 孤独量表（简式）评估焦虑、抑郁和孤独症状。我们使用多变量逻辑回归来估计歧视与心理健康之间的关联。总体而言，42.7% 的参与者表示每月遭受一次或更多次歧视。与没有歧视相比，每月经历一次歧视与焦虑（调整后优势比 [aOR] = 2.60，95% CI = 1.38–4.77）、抑郁（aOR = 2.58，95% CI = 1.46–4.56）的几率增加相关。和孤独感（aOR = 2.86，95% CI = 1.75–4.67）。每周经历一次或更多次歧视与焦虑（aOR = 6.90，95% CI = 3.71–12.83）、抑郁（aOR = 6.96，95% CI = 3.80–12.74）和孤独感（aOR = 6.91，95% CI = 3.38–13.00）。歧视对心理健康有害，即使发生频率相对较低；然而，更频繁的歧视与更严重的心理健康症状有关。迫切需要针对反 A/PI 仇恨和减少 A/PI 心理健康负担的公共卫生干预措施和计划。