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Olfactory dysfunction and the role of stem cells in the regeneration of olfactory neurons
Heliyon ( IF 4 ) Pub Date : 2024-04-18 , DOI: 10.1016/j.heliyon.2024.e29948
Pengju Yu , Weiguan Chen , Ling Jiang , Yufeng Jia , Xiaoyan Xu , Weiye Shen , Ni Jin , Hongjie Du

The prevalence of COVID-19 has drawn increasing attention to olfactory dysfunction among researchers. Olfactory dysfunction manifests in various clinical types, influenced by numerous pathogenic factors. Despite this diversity, the underlying pathogenesis remains largely elusive, contributing to a lack of standardized treatment approaches. However, the potential regeneration of olfactory neurons within the nasal cavity presents a promising avenue for addressing olfactory dysfunction effectively. Our review aims to delve into the current research landscape and treatment modalities concerning olfactory dysfunction, emphasizing etiology, pathogenesis, clinical interventions, and the role of stem cells in regenerating olfactory nerves. Through this comprehensive examination, we aim to provide valuable insights into understanding the onset, progression, and treatment of olfactory dysfunction diseases.

中文翻译:

嗅觉功能障碍和干细胞在嗅觉神经元再生中的作用

COVID-19 的流行引起了研究人员对嗅觉功能障碍的越来越多的关注。嗅觉功能障碍有多种临床类型,受多种致病因素影响。尽管存在这种多样性,但潜在的发病机制在很大程度上仍然难以捉摸,导致缺乏标准化的治疗方法。然而,鼻腔内嗅觉神经元的潜在再生为有效解决嗅觉功能障碍提供了一条有希望的途径。我们的综述旨在深入探讨当前有关嗅觉功能障碍的研究现状和治疗方式,强调病因、发病机制、临床干预以及干细胞在嗅觉神经再生中的作用。通过这项全面的检查,我们的目标是为了解嗅觉功能障碍疾病的发病、进展和治疗提供有价值的见解。
更新日期:2024-04-18
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