Inhaled air pollutants (AirP) comprise extraordinarily diverse particles, volatiles, and gases from traffic, wildfire, cigarette smoke, dust, and various other sources. These pollutants contain numerous toxic components which collectively differ in relative levels of components, but broadly share chemical classes. Exposure and health outcomes from AirP are complex, depending on pollutant source, duration of exposure, and socioeconomic status. We discuss examples in the current literature on organ responses to AirP, with a focus on lung, arteries, and brain. Some transcriptional responses are shared. It is well accepted that AirP contributes to Alzheimer’s disease and other neurodegenerative conditions in the Gero-Exposome. However, we do not know which chemical compounds initiate these changes and how activation of these transcriptional pathways is further modified by genetics and prenatal development.

中文翻译：

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Gero-Exposome 的吸入污染物与晚年健康

吸入空气污染物 (AirP) 包括来自交通、野火、香烟烟雾、灰尘和各种其他来源的极其多样的颗粒、挥发物和气体。这些污染物含有多种有毒成分，这些成分的相对含量总体上有所不同，但化学类别大致相同。 AirP 的暴露和健康结果很复杂，具体取决于污染物来源、暴露持续时间和社会经济状况。我们讨论当前文献中有关 AirP 器官反应的例子，重点关注肺、动脉和大脑。一些转录反应是共享的。人们普遍认为，AirP 会导致 Gero-Exposome 中的阿尔茨海默病和其他神经退行性疾病。然而，我们不知道哪些化合物引发这些变化，也不知道这些转录途径的激活如何通过遗传学和产前发育进一步改变。