This study establishes in vitro and in vivo systems to study mutagenesis and cancer genome evolution. Using microfluidics and mouse models, the method enables the dissection of co-occurring mutational processes and reveals that acute damage results in mirror-image mutation phasing between sister cells after a single mitosis.

中文翻译：

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寻找失踪的姐妹：哺乳动物有丝分裂姐妹细胞的镜像突变阶段

这项研究建立了体外和体内系统来研究突变和癌症基因组进化。使用微流体和小鼠模型，该方法能够剖析同时发生的突变过程，并揭示急性损伤会导致单次有丝分裂后姐妹细胞之间的镜像突变定相。