INTRODUCTIONWe investigated the association between white matter hyperintensities (WMH) and regional cortical thickness, amyloid and tau deposition, and synaptic density in the WMH‐connected cortex using multimodal images.METHODSWe included 107 participants (59 with Alzheimer's disease [AD]; 27 with mild cognitive impairment; 21 cognitively normal controls) with amyloid beta (Aβ) positivity on amyloid positron emission tomography (PET). The cortex connected to WMH was identified using probabilistic tractography.RESULTSWe found that WMH connected to the cortex with more severe regional degeneration as measured by cortical thickness, Aβ and tau deposition, and synaptic vesicle glycoprotein 2 A (SV2A) density using 18F‐SynVesT‐1 PET. In addition, higher ratios of Aβ in the deep WMH‐connected versus WMH‐unconnected cortex were significantly related to lower cognitive scores. Last, the cortical thickness of WMH‐connected cortex reduced more than WMH‐unconnected cortex over 12 months.DISCUSSIONOur results suggest that WMH may be associated with AD‐intrinsic processes of degeneration, in addition to vascular mechanisms.Highlights We studied white matter hyperintensities (WMHs) and WMH‐connected cortical changes. WMHs are associated with more severe regional cortical degeneration. Findings suggest WMHs may be associated with Alzheimer's disease–intrinsic processes of degeneration.

中文翻译：

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将白质高信号与阿尔茨海默氏病的区域皮质变薄、淀粉样蛋白沉积和突触密度损失联系起来

简介我们使用多模态图像研究了白质高信号 (WMH) 与区域皮质厚度、淀粉样蛋白和 tau 蛋白沉积以及 WMH 连接皮质中的突触密度之间的关联。方法我们纳入了 107 名参与者（59 名患有阿尔茨海默病 [AD]；27 名患有轻度）认知障碍；21 名认知正常对照），淀粉样蛋白正电子发射断层扫描 (PET) 呈阳性。使用概率纤维束描记法识别与 WMH 连接的皮层。结果我们发现，通过皮层厚度、Aβ 和 tau 沉积以及突触小泡糖蛋白 2 A (SV2A) 密度测量，WMH 连接到的皮层具有更严重的区域退化。18F-SynVesT-1 PET。此外，与 WMH 未连接的深层皮层相比，与 WMH 未连接的深层皮层中 Aβ 的比例较高，与较低的认知得分显着相关。最后，在 12 个月内，WMH 连接皮质的皮质厚度比 WMH 未连接皮质减少更多。讨论我们的结果表明，除了血管机制之外，WMH 可能还与 AD 内在的退化过程相关。 我们研究了白质高信号 (WMH) 和 WMH 相关的皮质变化。 WMH 与更严重的区域皮质变性有关。 研究结果表明，WMH 可能与阿尔茨海默病——内在的退化过程有关。