In this issue of Cell Chemical Biology, Gries et al.¹ employ an innovative screening approach to identify anti-tuberculosis compounds with dual modes of action: anti-virulence against the type VII secretion system ESX-1 and enhanced ethionamide efficacy. These compounds hold promise for developing multi-target tuberculosis drugs with potential clinical applications.

中文翻译：

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双重作用化合物对结核病发挥一拖二的作用

在本期《细胞化学生物学》中，Gries 等人。¹采用创新的筛选方法来鉴定具有双重作用模式的抗结核化合物：抗 VII 型分泌系统 ESX-1 的毒力和增强乙硫异烟胺功效。这些化合物有望开发具有潜在临床应用的多靶点结核病药物。