While the tissue-transparent fluorescence of single-walled carbon nanotubes (SWCNTs) imparts substantial potential for use in non-invasive biosensors, the development of non-invasive systems is yet to be realized. Here, the functionality of a SWCNT-based nanosensor in several injectable SWCNT-hydrogel systems, ultimately finding SWCNT encapsulation in a sulfonated methylcellulose hydrogel optimal for detection of ions, small molecules, and proteins is investigated. It is found that the hydrogel system and nanosensor signal are stable for several weeks in live mice. Then, it is found that this system successfully detects local injections of the chemotherapeutic agent doxorubicin in mice. Future studies to adapt this device for the detection of other analytes in animals and, ultimately, patients are anticipated.

中文翻译：

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无创注射光学纳米传感器-水凝胶混合体检测活体小鼠中的阿霉素

虽然单壁碳纳米管 (SWCNT) 的组织透明荧光赋予其在非侵入性生物传感器中使用的巨大潜力，但非侵入性系统的开发尚未实现。在这里，研究了基于单壁碳纳米管的纳米传感器在几种可注射单壁碳纳米管-水凝胶系统中的功能，最终发现磺化甲基纤维素水凝胶中的单壁碳纳米管封装最适合检测离子、小分子和蛋白质。研究发现，水凝胶系统和纳米传感器信号在活体小鼠体内可稳定数周。然后，发现该系统成功地检测到小鼠体内化疗药物阿霉素的局部注射。未来的研究有望使该设备用于检测动物中的其他分析物，并最终检测患者的其他分析物。